"The Effects of Wing Bud Extirpation on the Development of the Central Nervous System in Chick Embryos" (1934), by Viktor Hamburger

German embryologist Viktor Hamburger [4] came to the US in 1932 with a fellowship provided by the Rockefeller Foundation [5]. Hamburger started his research in Frank Rattray Lillie?s laboratory at the University of Chicago [6]. His two-year work on the development of the central nervous system [7] (CNS) in chick [8] embryos was crystallized in his 1934 paper, ?The Effects of Wing Bud Extirpation on the Development of the Central Nervous System in Chick Embryos,? published in The Journal of Experimental Zoology [9]. Hamburger was able to use the microsurgical techniques that he had learned from Hans Spemann [10] to show how wing buds influence the development of the CNS in chick [8] embryos. This paper is one of several among Hamburger?s important studies on chick [8] embryos and represents the empirical and theoretical cornerstone for his further research on central-peripheral relations in the development of the nervous system.